Zerbinati N, Marotta F, Nagpal R, Singh B, Mohania D, Milazzo M, Sapienza C, Italia A, Tomella C, Catanzaro R.
RAGE regulates cellular proliferation in hepatocellular carcinoma (HCC) and the aim of this study was to test the in vitro effect of YHK, a nutraceutical with prior data suggesting its hepatocyte protecting role, in regulating RAGE in the proliferation of HCC cell line HuH7 as well checking also its potential modulation in the expression of the transcriptional factor NF-κB p65. Our study showed that YHK significantly reduced cellular growth in the HuH7 cell line (p<0.05). Moreover, this phytocompound partly reduced gene expression of NF-κB p65 (by 35%, p<0.05). These data suggest that YHK has a potential role as a modulator of RAGE and RAGE-ligands for potential healthy-liver intervention in HCC prevention strategies.
Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]