Cardioprotective effect of a biofermented nutraceutical on endothelial function in healthy middle-aged subjects

Marotta F, Yadav H, Kumari A, Catanzaro R, Jain S, Polimeni A, Lorenzetti A, Soresi V.
Rejuvenation Res. 2012 Apr;15(2):178-81.
1 ReGenera Res Group for Aging Intervention , Milan, Italy .

We tested a biofermented nutraceutical (FPP) that has been previously shown to positively modulate nitric oxide (NO). Forty-two healthymiddle-aged subjects were given 3 grams of FPP three times a day for 6 weeks, and tests were repeated at 3 and 6 weeks; the control group was given a placebo. Flow-mediated dilation (FMD) was measured together with NO compounds (nitrogen oxides [NOx]: NO(2)(-)+NO(3)(-)) plasma levels and asymmetrical dimethylarginine (ADMA). In the interventional group, overall FMD significantly increased from 4.2% to 7.3% (p<0.05 vs. placebo). A significant increase in plasma NO and a decrease in ADMA were detected after consumption of FPP (p<0.01). Although larger studies are awaited, it appears that, at least in healthy individuals, such nutraceutical intervention by positively acting on significant cardiovascular parameters can be considered in the armamentarium of a proactive age-management strategy.