Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial

Joao Tome ́-Carneiro1, Manuel Gonza ́lvez2, Mar Larrosa1, Francisco J. Garc ́ıa-Almagro2, Francisco Avile ́s-Plaza3, Soledad Parra3, Mar ́ıa J. Ya ́n ̃ez-Gasco ́n1, Jose ́ A. Ruiz-Ros2, Mar ́ıa T. Garc ́ıa-Conesa1, Francisco A. Toma ́s-Barbera ́n1 and Juan Carlos Esp ́ın1
1 Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain
2 Cardiology Service, Morales Meseguer University Hospital, Murcia, Spain
3 Clinical Analyses Service, Virgen de La Arrixaca University Hospital, Murcia, Spain
Scope: The cardioprotective role of resveratrol as part of the human diet is not yet clear. Our aim was to investigate the effect of a grape supplement containing 8 mg resveratrol in oxidized LDL (LDLox), apolipoprotein-B (ApoB), and serum lipids on statin-treated patients in primary cardiovascular disease prevention (PCP).
Methods and results: A triple-blind, randomized, placebo-controlled trial was conducted. Seventy-five patients (three parallel arms) consumed one capsule (350 mg) daily for 6 months containing resveratrol-enriched grape extract (GE-RES, Stilvid⃝R ), grape extract (GE, similar polyphenolic content but no resveratrol), or placebo (maltodextrin). After 6 months, no changes were observed in the placebo group and only LDL cholesterol (LDLc) decreased by 2.9% (p = 0.013) in the GE group. In contrast, LDLc (−4.5%, p = 0.04), ApoB (−9.8%, p = 0.014), LDLox (−20%, p = 0.001), and LDLox/ApoB (−12.5%, p = 0.000) decreased in the Stilvid⃝R group, whereas the ratio non-HDLc (total atherogenic cholesterol load)/ApoB increased (8.5%, p = 0.046). No changes were observed in hepatic, thyroid, and renal function. No adverse effects were observed in any of the patients.
Conclusion: This GE-RES reduced atherogenic markers and might exert additional cardiopro- tection beyond the gold-standard medication in patients from PCP. The presence of resveratrol in the GE was necessary to achieve these effects.
Keywords:
Cardiovascular / Clinical trial / Nutraceutical / Polyphenol / Resveratrol

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