EXPANDING METCHNIKOFF POSTULATE: ORAL HEALTH IS CRUCIAL IN A GLOBAL SUCCESSFUL AGING MANAGEMENT STRATEGY.

Illuzzi N, Galli R, Kushugulova A, Zhumadilov Z, Licciardello O, Marotta F.

Abstract

The mouth offers an unique opportunity to the physician and dental hygenist to evaluate and monitor a number of early nutritional-related diseases and vitamin deficiencies in still healthy people. Increasing evidences suggest that periodontal disease might be associated to several systemic diseases (diabetes, immunosuppression, obesity, hormonal changes). Conversely, an oral/periodontal disease might be the perpetuating factor or possibly the trigger of chronic illnesses via the activation of proinflammatory cytokines from monocytes and polymorphonuclear leukocytes in subgingival biofilm and oral microbiome unbalance. Office-based microbiological and susceptibility genomic testing in the oral cavity (ex. BACTOdent-DENTYgen, 4P-Genomics, Luxenbourg) are expected to be widespread tools in a global approach for an age-management strategy connecting oral health and personalized solutions.

Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]