PROTECTIVE EFFECT OF A STURGEON EGG HOMOGENATE MARINE COMPOUND ON ARTERIAL ULTRASTRUCTURE IN SPONTANEOUS HYPERTENSIVE RATS.

Zerbinati N, Marotta F, Nagpal R, Singh B, Mohania D, Milazzo M, Sapienza C, Italia A, Tomella C, Catanzaro R.

Abstract

We assessed the effect of a sturgeon eggs-based nutraceutical (LD-1227) versus EPA/DHA on the ultrastructure of spontaneously hypertensive rats (SHR) aorta. Sixty SHR were randomly divided into three groups fed: a). rat chow; b) added with 10mg EPA/DHA; c) added with 10mg of LD-1227 for 18 weeks. Afterwards, the aorta was used for: blind measurements of thickened intima area and electron microscopic examination. Control SHR showed an expanded subendothelial space and leukocytes intima-infiltration which were reduced in LD-1227-fed rats (p<0.05) and less in EPA/DHA-group. TEM showed endothelial alteration with severe subcellular injury and, unlike EPA-DHA-group, LD-1227-treated rats displayed a significant reduction (p<0.05). These data suggest that LD-1227 has stronger arterial protective-properties and deserves further work in view of a preventive medicine strategy.

Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]